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KCNJ2

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features.
Protein class

Disease related genes, FDA approved drug targets, Human disease related genes, Transporters, Voltage-gated ion channels

Predicted location

Membrane

Single cell type specificity

Group enriched (Horizontal cells, Oligodendrocytes)

Immune cell specificity

Immune cell enriched (neutrophil)

Cell line specificity

Cell line enhanced (hTERT-RPE1, HUVEC TERT2, REH, RH-30, U-138 MG)

Interaction

Homomultimeric and heteromultimeric association with KCNJ4/Kir2.3. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its localization and trafficking (By similarity).

Molecular function

Ion channel, Voltage-gated channel

More Types Infomation

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