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KIF3A
Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitement of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Horizontal cells, Excitatory neurons, Inhibitory neurons, Spermatocytes)
Immune cell specificity
Immune cell enriched (basophil)
Cell line specificity
Low cell line specificity
Interaction
Heterodimer of KIF3A and KIF3B (By similarity). Interacts with PIFO (PubMed:20643351). Interacts with CLN3 (PubMed:22261744). Interacts with DCTN1 (By similarity). Interacts with FLCN (PubMed:27072130). Interacts with AP3B1 (PubMed:19934039).
Molecular function
Motor protein
More Types Infomation
- Rabbit Anti-KIF3A Polyclonal Antibody (MRO-1995-CN) (MRO-1995-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC, FC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP, FC
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- Species Reactivity: Rat
- Application: BL, ICC/IF, WB
- Recombinant Mouse Anti-KIF3A Antibody (K2.4) (NEUT-1625CQ)
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- Species Reactivity: Rat, Xenopus laevis, Sea urchin
- Type: IgG1
- Application: BL, ICC/IF, WB
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For Research Use Only. Not For Clinical Use.