Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins
Intracellular, Secreted (different isoforms)
Cell type enriched (Hepatocytes)
Not detected in immune cells
Cell line enhanced (NTERA-2, SCLC-21H, U-937)
Forms a heterodimer with SERPINA5. The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds.
Hydrolase, Protease, Serine protease
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For Research Use Only. Not For Clinical Use.