LAT

Disease related genes, Plasma proteins, RAS pathway related proteins

Intracellular, Membrane (different isoforms)

Group enriched (NK-cells, T-cells, dendritic cells, granulocytes, Macrophages)

Group enriched (T-reg, basophil, memory CD8 T-cell, gdT-cell, memory CD4 T-cell, naive CD4 T-cell, naive CD8 T-cell, MAIT T-cell, NK-cell)

Cell line enhanced (HEL, HMC-1, MOLT-4)

When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS, VAV, and LCP2. Interacts with SHB, SKAP2 and CLNK (By similarity). Interacts with FCGR1A. Interacts with GRB2, PLCG1 and THEMIS upon TCR activation in thymocytes (By similarity). Interacts with THEMIS2 (By similarity).