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LATS2
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Early spermatids)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Low cell line specificity
Interaction
Interacts with and is phosphorylated by AURKA. Binds to AR. Interacts with AJUBA during mitosis and this complex regulates organization of the spindle apparatus through recruitment of gamma-tubulin to the centrosome. Interacts (via PPxY motif) with YAP1 (via WW domains). Interacts with MOB1A and MOB1B. Interacts with LIMD1, WTIP and AJUBA. Interacts with SNAI1.
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
More Types Infomation
- Rabbit Anti-Human LATS2 Antibody (MOB-0302MC)
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- Species Reactivity: Human, Mouse
- Application: WB, IHC, IF, ELISA, FACS
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- Species Reactivity: Human
- Application: IHC-P, WB
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For Research Use Only. Not For Clinical Use.