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LGALS9

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkins disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene.
Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Hofbauer cells, Kupffer cells, Intestinal goblet cells, Paneth cells, Distal enterocytes, Gastric mucus-secreting cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (HL-60, HMC-1, MOLT-4, REH, THP-1, U-937)

Interaction

Monomer.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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