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LHX6

This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.
Protein class

Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Late spermatids, Early spermatids, Inhibitory neurons, Endothelial cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (CACO-2, K-562, NB-4, PC-3, U-87 MG)

Interaction

Interacts with LDB1 (via the LIM zinc-binding domains).

Molecular function

Developmental protein, DNA-binding

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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