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LTC4S
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Membrane
Single cell type specificity
Cell type enriched (granulocytes)
Immune cell specificity
Group enriched (eosinophil, basophil)
Cell line specificity
Cell line enriched (HMC-1)
Interaction
Homotrimer (PubMed:17632548, 17632546). Interacts with ALOX5AP and ALOX5 (PubMed:19233132).
Molecular function
Lyase, Transferase
More Types Infomation
- Recombinant Mouse Anti-LTC4S Antibody (mAbLTC) (NEUT-1711CQ)
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- Species Reactivity: Human
- Type: IgG1, κ
- Application: ELISA, RIA, BL
- Recombinant Anti-Human LTC4S Antibody scFv Fragment (MOB-2181z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: IF, FC, Biosensors, FuncS
- Recombinant Anti-Human LTC4S Antibody Fab Fragment (MOB-2181z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: IP, RIA, FuncS
- Recombinant Anti-Human LTC4S Antibody (MOB-2181z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, FuncS
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For Research Use Only. Not For Clinical Use.