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MARCKSL1
This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (monocytes)
Immune cell specificity
Immune cell enriched (eosinophil)
Cell line specificity
Cell line enhanced (AF22, NTERA-2)
Interaction
Binds to filamentous actin (F-actin), but not to monomeric G-actin, independently of its phosphorylation status.
Molecular function
Actin-binding, Calmodulin-binding
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, IHC-P, ICC/IF, FC
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- Species Reactivity: Human
- Application: WB
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For Research Use Only. Not For Clinical Use.