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MERTK
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Astrocytes, Microglial cells, Kupffer cells, Macrophages)
Immune cell specificity
Group enriched (intermediate monocyte, non-classical monocyte)
Cell line specificity
Cell line enhanced (CACO-2, Hep G2, HUVEC TERT2, RT4)
Interaction
Interacts (upon activation) with TNK2; stimulates TNK2 autophosphorylation. Interacts (via N-terminus) with extracellular ligands LGALS3, TUB, TULP1 and GAS6 (By similarity). Interacts with VAV1 in a phosphotyrosine-independent manner. Interacts with TIMD4; this interaction enhances TIMD4-mediated efferocytosis (PubMed:32640697).
Molecular function
Kinase, Receptor, Transferase, Tyrosine-protein kinase
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, IP, FC
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
- Recombinant Mouse Anti-MERTK Antibody (Y323) (NEUT-1725CQ)
-
- Species Reactivity: Human
- Type: IgG
- Application: BL, WB, IP, IHC-P
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IP
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, IP
- Mouse Anti-MERTK Recombinant Antibody (HPAB-0216-CN) (HPAB-0216-CN)
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
- Mouse Anti-MERTK Recombinant Antibody (HPAB-0215-CN) (HPAB-0215-CN)
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: WB, ELISA
- Mouse Anti-MERTK Recombinant Antibody (clone 7E5G1) (VS3-XY1063)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
-
- Derivation: Rabbit
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, IP
-
- Species Reactivity: Human
- Type: Humanized IgG4
- Application: ELISA
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, IP
- Mouse Anti-MERTK Recombinant Antibody; scFv Fragment (HPAB-0216-CN-S(P)) (HPAB-0216-CN-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: WB, ELISA
- Mouse Anti-MERTK Recombinant Antibody; scFv Fragment (HPAB-0215-CN-S(P)) (HPAB-0215-CN-S(P))
-
- Species Reactivity: Human, Mouse
- Type: Mouse scFv
- Application: WB, ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, WB, IF, FC
-
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
-
- Species Reactivity: Mouse
- Type: Rat IgG2a, κ
- Application: FC, FuncS, IF, IHC-Fr, WB, IP
- Mouse Anti-MERTK Recombinant Antibody; Fab Fragment (HPAB-0216-CN-F(E)) (HPAB-0216-CN-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: WB, ELISA
- Mouse Anti-MERTK Recombinant Antibody; Fab Fragment (HPAB-0215-CN-F(E)) (HPAB-0215-CN-F(E))
-
- Species Reactivity: Human, Mouse
- Type: Mouse Fab
- Application: WB, ELISA
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For Research Use Only. Not For Clinical Use.