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MFAP5
This gene encodes a 25-kD microfibril-associated glycoprotein which is a component of microfibrils of the extracellular matrix. The encoded protein promotes attachment of cells to microfibrils via alpha-V-beta-3 integrin. Deficiency of this gene in mice results in neutropenia. Alternate splicing results in multiple transcript variants encoding different isoforms.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Extravillous trophoblasts, Fibroblasts, Syncytiotrophoblasts, Cytotrophoblasts)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Cell line enhanced (BEWO, BJ, EFO-21, HeLa, SuSa)
Interaction
Interacts with TGFB2. Interacts with BMP2. Interacts with FBN1 (via N-terminal domain) and FBN2.
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC-P
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For Research Use Only. Not For Clinical Use.