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MICB
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants.
Protein class
Disease related genes
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Kupffer cells, monocytes, T-cells, Hofbauer cells, Erythroid cells, dendritic cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (U-266/70, U-266/84)
Interaction
Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICB while HCST acts as an adapter molecule which enables signal transduction. Receptor-ligand interaction induces clustering of both proteins in ordered structures called immune synapses and also leads to their intercellular transfer. This is associated with a reduction in the cytotoxicity of KLRK1-expressing cells. (Microbial infection) Interacts with human cytomegalovirus/HHV-5 glycoprotein UL16; this interaction causes sequestration of MICB in the endoplasmic reticulum and increases resistance to KLRK1-mediated cytotoxicity.
More Types Infomation
- Recombinant Mouse Anti-MICB Antibody (CBL145) (NEUT-1740CQ)
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- Species Reactivity: Human
- Type: IgG2
- Application: FC, WB, IHC, Neut
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- Species Reactivity: Human
- Application: FC, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, ELISA
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- Species Reactivity: Human
- Type: IgG
- Application: ELISA
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- Species Reactivity: Human
- Type: IgG
- Application: WB
- Rabbit Anti-MICB Recombinant Antibody (VS-0723-WK236) (VS-0723-WK236)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, FC
- Mouse Anti-MICB Recombinant Antibody (HPAB-N0178-YC) (HPAB-N0178-YC)
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- Species Reactivity: Human
- Type: Mouse IgG2
- Application: ELISA, FC
- Anti-Human MICB Recombinant Antibody (TAB-526CL)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
- Human Anti-MICB Antibody, mRNA (TAB-526CL-mRNA)
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- Species Reactivity: Human
- Mouse Anti-MICB Recombinant Antibody; scFv Fragment (HPAB-N0178-YC-S(P)) (HPAB-N0178-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Mouse Anti-MICB Recombinant Antibody; Fab Fragment (HPAB-N0178-YC-F(E)) (HPAB-N0178-YC-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
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For Research Use Only. Not For Clinical Use.