Enzymes, Metabolic proteins
Intracellular
Low cell type specificity
Low immune cell specificity
Cell line enhanced (HHSteC)
Monomer. Interacts with the C-terminal regions of EIF4G1 and EIF4G2; this interaction is promoted when MAPK pathways are repressed but repressed upon ERK proteins activation. Also binds to dephosphorylated MAPK3/ERK1 and MAPK1/ERK2. Isoform 1 interaction with phosphorylated MAPK3/ERK1 and MAPK1/ERK2 protects it from dephosphorylation and inactivation. Isoform 2 interacts with ESR2 and EIF4E in the nucleus.
Kinase, Serine/threonine-protein kinase, Transferase
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For Research Use Only. Not For Clinical Use.