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MSH2
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. Coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the DNA mismatch repair (MMR) complex composed at least of MSH2, MSH3, MSH6, PMS1 and MLH1 (PubMed:26300262). Heterodimer consisting of MSH2-MSH6 (MutS alpha) or MSH2-MSH3 (MutS beta) (PubMed:8942985). Both heterodimers form a ternary complex with MutL alpha (MLH1-PMS1) (PubMed:9788596, PubMed:10856833, PubMed:11427529, PubMed:11429708, PubMed:12414623, PubMed:14676842). Interacts with MCM9; the interaction recruits MCM9 to chromatin (PubMed:26300262). Interacts with MCM8 (PubMed:26300262). Interacts with EXO1 (PubMed:9788596, PubMed:10856833, PubMed:11427529, PubMed:11429708, PubMed:12414623, PubMed:14676842). Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex (PubMed:10783165). This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains (PubMed:10783165). Interacts with ATR (PubMed:14657349). Interacts with SLX4/BTBD12; this interaction is direct and links MutS beta to SLX4, a subunit of different structure-specific endonucleases (PubMed:19596235). Interacts with SMARCAD1 (PubMed:18675275).
Molecular function
DNA-binding
More Types Infomation
- Recombinant Mouse Anti-MSH2 Monoclonal Antibody (10G3) (MRO-1028-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG2b
- Application: WB, IHC
- Recombinant Mouse Anti-MSH2 Monoclonal Antibody (10G2) (MRO-1027-CN)
-
- Species Reactivity: Human, Rat
- Type: Mouse IgG2b
- Application: WB, IHC
- Recombinant Mouse Anti-MSH2 Monoclonal Antibody (10G1) (MRO-1026-CN)
-
- Species Reactivity: Human, Rat
- Type: Mouse IgG2b
- Application: WB, IHC
- Rabbit Anti-MSH2 Polyclonal Antibody (MRO-2044-CN) (MRO-2044-CN)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: IF, FC
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-Fr, WB
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: FC, ICC/IF, IHC-P, WB
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, ELISA
-
- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB
-
- Type: Mouse IgG1
- Application: ELISA, ICC, FC
-
- Type: Mouse IgG2a
- Application: ELISA, WB, IHC, FC
-
- Type: Mouse IgG1
- Application: ELISA, ICC, WB, FC, IHC
-
- Type: Mouse IgG1
- Application: ELISA, WB, ICC, FC
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC-Fr, IHC-P, WB, IP, IF
- Mouse Anti-MSH2 Recombinant Antibody (VS3-CJ961) (VS3-CJ961)
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC
-
- Species Reactivity: human
- Type: Rabbit IgG
- Application: IHC-P
-
- Species Reactivity: Human, Monkey
- Type: Mouse IgG
- Application: WB, IHC, IF, ELISA
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For Research Use Only. Not For Clinical Use.