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MTHFD2
This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009]
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Langerhans cells, Smooth muscle cells, monocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer.
Molecular function
Hydrolase, Multifunctional enzyme, Oxidoreductase
More Types Infomation
- Recombinant Mouse Anti-Human MTHFD2 Antibody (MOB-0935MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P
- Recombinant Mouse Anti-MTHFD2 Antibody (VS-0923-FY114) (VS-0923-FY114)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
- Chicken Anti-MTHFD2 Polyclonal IgY (BRD-0377MZ)
-
- Species Reactivity: Human, Mouse
- Type: Chicken antibody
- Application: WB
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG1, κ
- Application: WB
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For Research Use Only. Not For Clinical Use.