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NEK2

The Nek family includes Nek1~11, where Nek2 is most similar to the centrosome, and Nek2 is located on chromosome 1q32. The expression of 2-1q41Nek2 includes three variable splicing Nek2A, Nek2B and Nek2C, of which Nek2A is most common in tumor tissues. Centrosome-associated kinase 2 (Nek2) is a cell cycle-regulated egg with serine/threonine kinase activity similar to the centrosome structure. Nek2 regulates the cell cycle by stabilizing microtubule centrosome replication and separation processes, centromere attachment and checkpointing of spindle assembly. Abnormal expression of NEK2 affects the normal progression of cell mitosis, and chromatin polyploid formation and chromatin instability are the two most common phenomena in tumor cells. NEK2 regulates cell proliferation by affecting cell mitosis. Abnormal expression of NEK2 leads to abnormal cell cycle regulation, resulting in abnormal cell proliferation, which leads to tumor development and development. Recent studies have found that Nek2 can promote the occurrence and metastasis of breast cancer, liver cancer and lung cancer by increasing the mechanisms of tumor formation, drug resistance and invasion. Although Nek2 is relatively conservative in evolution, it has been shown to play an important role in the invasion and migration of various tumors such as liver cancer, prostate cancer, and ovarian cancer. The study found that the Nek family is widely involved in regulating tumor proliferation and metastasis. In liver cancer tissues, Nek2 mainly inhibits the metastasis of hepatoma cells through the MAPK pathway; in prostate cancer tissues, Nek2 changes cell proliferation through PI3K-AKT-mTOR signaling pathway; in ovarian cancer tissues, Nek2 changes through ERK signal transduction pathway biological behavior of SKOV3 ovarian cancer cell lines. The relationship between Nek2 and renal cell carcinoma has been studied. The use of gene enrichment analysis for papillary renal cell carcinoma has revealed the enrichment and expression of Nek2, KIF14 and other genes in chromosome 1q and the progression of papillary renal cell carcinoma. The number of gene copies is closely related in the lethal patients increased significantly. In liver cancer, down-regulation of Nek2 can inhibit HepG2 cell proliferation, promote apoptosis, and inhibit migration. Nek2 is also considered to be an important marker for the prognosis and progression of liver cancer.

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