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NETO2

This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Protein class

Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Inhibitory neurons, Theca cells, Excitatory neurons, Oligodendrocyte precursor cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Low cell line specificity

Interaction

Interacts with GRIK2 and GRIK3, but neither with AMPA-nor with NMDA-sensitive glutamate receptors.

Molecular function

Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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