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NEUROD1
This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus.
Protein class
Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Enteroendocrine cells, Rod photoreceptor cells, Cone photoreceptor cells, Bipolar cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enriched (SCLC-21H)
Interaction
Efficient DNA-binding requires dimerization with another bHLH protein (By similarity). Heterodimer with TCF3/E47; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E-box element (PubMed:14752053). Interacts with EP300; the interaction is inhibited by NR0B2 (PubMed:14752053). Interacts with RREB1 (PubMed:12482979). Interacts with ATOH8 (By similarity).
Molecular function
Activator, Developmental protein, DNA-binding
More Types Infomation
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- Species Reactivity: Human
- Application: ICC/IF, IHC-P, WB, sELISA
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: IP, WB
- Mouse Anti-NEUROD1 Recombinant Antibody (clone 6E6) (VS3-XY1157)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
- Mouse Anti-NEUROD1 Recombinant Antibody (clone 3H2) (VS3-XY1156)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP
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For Research Use Only. Not For Clinical Use.