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NR0B1
This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Nuclear receptors, Plasma proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocyte precursor cells, Ionocytes, Enteroendocrine cells, Theca cells, monocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (A549, RT4)
Interaction
Homodimer. Interacts with NR5A1, NR5A2, NR0B2 and with COPS2. Interacts with ESRRB; represses ESRRB activity at the GATA6 promoter (By similarity).
Molecular function
Receptor, Repressor
More Types Infomation
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- Species Reactivity: Human
- Application: ELISA, WB
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, FC
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- Derivation: Rabbit
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ELISA
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For Research Use Only. Not For Clinical Use.