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NR1D1
This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013]
Protein class
Metabolic proteins, Nuclear receptors, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Squamous epithelial cells, Suprabasal keratinocytes)
Immune cell specificity
Immune cell enhanced (MAIT T-cell)
Cell line specificity
Cell line enhanced (Karpas-707)
Interaction
Binds DNA as a monomer or a homodimer (PubMed:9660968). Interacts with C1D, NR2E3 and SP1 (By similarity). Interacts with OPHN1 (via C-terminus) (PubMed:21874017). Interacts with ZNHIT1 (PubMed:17892483). Interacts with PER2; the interaction associates PER2 to ARNTL promoter region (PubMed:22170608). Interacts with CRY1 (PubMed:22170608). Interacts with CCAR2 (PubMed:23398316). Interacts with SIAH2 (PubMed:26392558). Interacts with CDK1 (By similarity). Interacts with FBXW7 (PubMed:27238018). Interacts with HUWE1 (PubMed:20534529). Interacts with NR0B2 (By similarity). Interacts with NFIL3 (By similarity). Interacts (via domain NR LBD) with HSP90AA1 and HSP90AB1 (By similarity).
Molecular function
Activator, DNA-binding, Receptor, Repressor
More Types Infomation
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- Species Reactivity: Human
- Application: IHC-P, WB
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: ICC/IF, IHC-P, WB
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, ELISA
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For Research Use Only. Not For Clinical Use.