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NR1D2
This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Protein class
Nuclear receptors, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Glandular and luminal cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Binds DNA as a monomer or a homodimer (PubMed:17870090). Interacts with NCOA5 coactivator, leading to a strong increase of transcription of target genes (PubMed:11113208). Interacts (via N-terminus) with KAT5 (PubMed:17996965). Interacts (via C-terminus) with HDAC1 (PubMed:17996965). Interacts with ZNHIT1 (PubMed:17892483). Interacts with SIAH2 (PubMed:26392558).
Molecular function
Activator, DNA-binding, Receptor, Repressor
More Types Infomation
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- Species Reactivity: Human
- Application: ICC/IF, WB
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For Research Use Only. Not For Clinical Use.