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NR4A1
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Protein class
Nuclear receptors, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Alveolar cells type 2, Glandular and luminal cells, Basal squamous epithelial cells)
Immune cell specificity
Group enriched (non-classical monocyte, intermediate monocyte)
Cell line specificity
Cell line enhanced (HeLa, MCF7, SK-BR-3, SK-MEL-30)
Interaction
Binds DNA as a monomer (By similarity). Interacts with GADD45GIP1 (PubMed:15459248). Interacts with STK11 (PubMed:22983157). Interacts with IFI27 (PubMed:22427340). Heterodimer (via DNA-binding domain) with RXRA (via C-terminus); DNA-binding of the heterodimer is enhanced by 9-cis retinoic acid (PubMed:17761950, PubMed:15509776). Competes for the RXRA interaction with EP300 and thereby attenuates EP300 mediated acetylation of RXRA (PubMed:17761950).
Molecular function
DNA-binding, Receptor
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, FC
- Recombinant Mouse Anti-NR4A1 Antibody (15-2) (NEUT-1790CQ)
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- Species Reactivity: Human
- Type: IgG1
- Application: Neut, FC
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IF, IP
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC
-
- Species Reactivity: Mouse
- Type: Mouse antibody
- Application: FC
-
- Species Reactivity: Rat
- Type: Rabbit IgG
- Application: WB
-
- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC
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For Research Use Only. Not For Clinical Use.