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NR5A2
The protein encoded by this gene is a DNA-binding zinc finger transcription factor and is a member of the fushi tarazu factor-1 subfamily of orphan nuclear receptors. The encoded protein is involved in the expression of genes for hepatitis B virus and cholesterol biosynthesis, and may be an important regulator of embryonic development.
Protein class
Nuclear receptors, Transcription factors, Transporters
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Granulosa cells)
Immune cell specificity
Group enriched (basophil, neutrophil)
Cell line specificity
Cell line enhanced (A549, CACO-2, HAP1, HMC-1, HUVEC TERT2)
Interaction
Binds DNA as a monomer (By similarity). Interacts with GRIP1, NCOA2 and NR0B2 (PubMed:15707893, PubMed:15723037, PubMed:15897460, PubMed:16289203). Interacts (when sumoylated) with GPS2; interaction with GPS2 onto hepatic acute phase protein promoters prevents N-Cor corepressor complex dissociation (PubMed:20159957).
Molecular function
Activator, DNA-binding, Receptor
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
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- Species Reactivity: Human
- Application: ELISA, IP, WB
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For Research Use Only. Not For Clinical Use.