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NRG1

The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).
Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins

Predicted location

Intracellular, Membrane, Secreted (different isoforms)

Single cell type specificity

Group enriched (Excitatory neurons, Inhibitory neurons)

Immune cell specificity

Immune cell enriched (classical monocyte)

Cell line specificity

Cell line enhanced (A549, BJ, fHDF/TERT166, GAMG, U-2197)

Interaction

The cytoplasmic domain interacts with the LIM domain region of LIMK1 (By similarity). Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4 (PubMed:20682778).

Molecular function

Growth factor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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