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OSM

This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Protein class

Cancer-related genes, Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Group enriched (Hofbauer cells, Macrophages)

Immune cell specificity

Group enriched (basophil, neutrophil)

Cell line specificity

Cell line enhanced (HDLM-2, HL-60, HMC-1, Karpas-707, NB-4)

Molecular function

Cytokine, Mitogen

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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