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OSMR

This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
OSMR
Protein class

Disease related genes, Human disease related genes, Plasma proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Basal prostatic cells, Prostatic glandular cells, Pancreatic endocrine cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (ASC TERT1, GAMG, HSkMC, U-2197)

Interaction

Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor.

Molecular function

Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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