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P2RX7
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.
Protein class
Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Excitatory neurons)
Immune cell specificity
Group enriched (intermediate monocyte, non-classical monocyte, classical monocyte, myeloid DC, T-reg, gdT-cell)
Cell line specificity
Cell line enhanced (Karpas-707, RPMI-8226, SK-MEL-30, U-266/70, U-266/84)
Interaction
Functional P2XRs are organized as homomeric and heteromeric trimers. Interacts with LAMA3, ITGB2, ACTB, ACTN4, SVIL, MPP3, HSPA1, HSPCB, HSPA8, PIK230 and PTPRB. Interacts (via C-terminus) with EMP2 (PubMed:12107182).
Molecular function
Ion channel, Ligand-gated ion channel, Receptor
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, ELISA, FC, IHC
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP, FC, ICC/IF
- Anti-Human P2RX7 Therapeutical Antibody (TAB-701CL)
-
- Species Reactivity: Human
- Type: Single domain antibodies (Nbs)
- Human Anti-P2RX7 Recombinant Antibody (TAB-0916CL) (TAB-0916CL)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: WB, FC
- Mouse Anti-P2RX7 Recombinant Antibody; Fab Fragment (HPAB-1590-FY-F(E)) (HPAB-1590-FY-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: Inhib
- Human Anti-P2RX7 Recombinant Antibody; scFv Fragment (TAB-0916CL-S(P)) (TAB-0916CL-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: WB, FC
- Human Anti-P2RX7 Antibody, mRNA (TAB-701CL-mRNA)
-
- Species Reactivity: Human
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, ELISA
- Mouse Anti-P2RX7 Recombinant Antibody; scFv Fragment (HPAB-1590-FY-S(P)) (HPAB-1590-FY-S(P))
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: Inhib
- Llama Anti-P2RX7 Recombinant Antibody (TAB-0079CL-VHH) (TAB-0079CL-VHH)
-
- Species Reactivity: Human
- Type: Llama VHH
- Application: FC
- Anti-Human P2RX7 VHH Single Domain Antibody (TAB-0078CL-VHH) (TAB-0078CL-VHH)
-
- Derivation: Phage display library
- Type: Single domain antibody
- Application: FC
- Human Anti-P2RX7 Recombinant Antibody; Fab Fragment (TAB-0916CL-F(E)) (TAB-0916CL-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: WB, FC
- Mouse Anti-P2RX7 Recombinant Antibody (HPAB-1590-FY) (HPAB-1590-FY)
-
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC
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For Research Use Only. Not For Clinical Use.