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PDE4B
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms.
Protein class
Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Oligodendrocytes, Oligodendrocyte precursor cells)
Immune cell specificity
Immune cell enhanced (neutrophil)
Cell line specificity
Cell line enhanced (AN3-CA, HUVEC TERT2, NTERA-2, SK-MEL-30, TIME, U-266/84)
Interaction
[Isoform PDE4B5]: Interacts with DISC1.
Molecular function
Hydrolase
More Types Infomation
Related Signaling Pathways
cAMP Signaling Pathway
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, FC
- Mouse Anti-PDE4B Recombinant Antibody (clone 1D12) (VS-0224-XY99)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1
- Application: WB, FC, IF, ICC, IHC, IHC-P
- Rabbit Anti-PDE4B Antibody (VS-0722-YJ175) (VS1-YJ175)
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- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: WB, IP
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For Research Use Only. Not For Clinical Use.