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PDGFRL

This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor.
Protein class

Disease related genes

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Fibroblasts, Leydig cells, Peritubular cells, Early spermatids)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (AN3-CA, BJ hTERT+, HSkMC)

Interaction

Forms a complex composed of PDGFRL, TNK2 and GRB2.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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