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PDK4
This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin.
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cardiomyocytes, Adipocytes, Proximal enterocytes, Smooth muscle cells, Kupffer cells)
Immune cell specificity
Group enriched (intermediate monocyte, non-classical monocyte, eosinophil, classical monocyte, myeloid DC)
Cell line specificity
Cell line enriched (ASC diff)
Interaction
Homodimer. Interacts with the pyruvate dehydrogenase complex subunit DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3).
Molecular function
Kinase, Transferase
More Types Infomation
Related Signaling Pathways
PPAR Signaling Pathway
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- Species Reactivity: Human
- Application: WB
- Mouse Anti-PDK4 Recombinant Antibody (VS3-WK1015) (VS3-WK1015)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
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For Research Use Only. Not For Clinical Use.