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PDLIM7

PDZ and LIM domain protein 7 (Pdlim7), also known as Enigma, is a member of the PDZ-LIM protein family and is co-expressed and bound to the transcription factors Tbx5 and Tbx4. The PDZ-LIM protein consists of an N-terminal PDZ domain and one or three C-terminal LIM structural cities. Both the PDZ domain and the LIM domain are protein interaction modules. A variety of interaction opportunities are provided for the multi-domain protein family. PDZ-LIM protein is involved in the regulation of signal transduction, cell migration and differentiation. Camarata et al believe that Pdlim7 is involved in actin cytoskeleton formation. Pdlim7 is involved in the assembly of actin filaments, which localize to actin filaments by colocalizing the Z-line in skeletal muscle through its PDZ domain and associated actin binding to the LIM domain while participating in gene expression regulation. The regulation of the skeleton can promote the differentiation and maturation of osteoblasts and bone formation.
Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Pancreatic endocrine cells, Exocrine glandular cells, Peritubular cells, Ductal cells, Sertoli cells, Smooth muscle cells)

Immune cell specificity

Group enriched (neutrophil, basophil, eosinophil)

Cell line specificity

Low cell line specificity

Interaction

Binds via its LIM zinc-binding 3 domain (LIM 3) to endocytic codes of INSR, but not with those of IGF1R, LDLR, TFRC, or EGFR. Interacts with various PKC isoforms through the LIM zinc-binding domains. Binds to RET in a phosphorylation-independent manner via its LIM zinc-binding domain 2 (LIM 2). Probably part of a complex with SHC and the RET dimer. Interacts with TPM2. Interacts with TBX4 and TBX5 (By similarity).

Molecular function

Developmental protein

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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