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PECAM1
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Adipocytes, Endothelial cells, Hepatic stellate cells, Macrophages)
Immune cell specificity
Immune cell enhanced (non-classical monocyte)
Cell line specificity
Group enriched (HUVEC TERT2, TIME)
Interaction
Trans-homodimer (via Ig-like C2-type 1 and Ig-like C2-type 2 domains); trans-homodimerization is required for cell-cell interaction (PubMed:26702061, PubMed:27958302). Forms a complex with BDKRB2 and GNAQ (PubMed:18672896). Interacts with BDKRB2 and GNAQ (PubMed:18672896). Interacts with PTPN11; Tyr-713 is critical for PTPN11 recruitment (PubMed:18388311, PubMed:19342684). Interacts with FER (By similarity). Interacts (via Ig-like C2-type domain 6) with CD177; the interaction is Ca(2+)-dependent; the interaction is direct (PubMed:17580308).
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, IHC
- Human Anti-PECAM1 Antibody (clone JC70), mRNA (FAMAB-1231CQ-mRNA)
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- Species Reactivity: Rabbit, Human, Mouse
-
- Species Reactivity: Human
- Type: IgG
- Application: ICC/IF, IF
- Recombinant Mouse Anti-PECAM1 Monoclonal Antibody (7-A1) (MRO-0294-CN)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG2a
- Application: WB, IF, IHC, FC
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, IP, FC
- Recombinant Rat Anti-Pecam1 Antibody (390) (NEUT-1856CQ)
-
- Species Reactivity: Mouse
- Type: IgG2a, κ
- Application: FC, IP, IHC-Fr, ICC, BL
- Recombinant Mouse Anti-PECAM1 Antibody (WM59) (NEUT-1855CQ)
-
- Species Reactivity: Human, African Green, Baboon, Cynomolgus, Rhesus
- Type: IgG1, κ
- Application: FC, IHC, IF, BL
- Recombinant Armenian Hamster Anti-PECAM1 Antibody (2H8) (NEUT-1854CQ)
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- Species Reactivity: Mouse, Hamster, Human
- Type: IgG
- Application: ELISA, IP, IHC, ICC, Neut, FC
- Mouse Recombinant Hamster Anti-PECAM1 Antibody (NEUT-1853CQ)
-
- Species Reactivity: Mouse
- Type: IgG
- Application: FC, FuncS
- Recombinant Mouse Anti-PECAM1 Antibody (HEC7) (NEUT-1852CQ)
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- Species Reactivity: Human, Rat, Bovine
- Type: IgG2a
- Application: BL, ELISA, FC, ICC/IF, IHC, IP, WB
- Human Anti-PECAM1 Recombinant Antibody (clone JC70) (FAMAB-1231CQ)
-
- Species Reactivity: Rabbit, Human, Mouse
- Type: Human IgG1
- Application: FACS, WB, IF, IHC
- Human Anti-PECAM1 Recombinant Antibody (clone BAG-85D10) (FAMAB-1230CQ)
-
- Species Reactivity: Human
- Type: Human IgG1
- Application: IHC
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: FC, IHC-P, IP, WB
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC
- Rabbit Anti-PECAM1 Polyclonal Antibody (MRO-1746-CN) (MRO-1746-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC, Block
-
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, WB, IHC, IF, FC
-
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, FACS, IF
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: ADCC enhanced antibody
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
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