Disease related genes, Human disease related genes
Intracellular
Cell type enhanced (Bipolar cells, Rod photoreceptor cells, Astrocytes, Horizontal cells)
Low immune cell specificity
Cell line enhanced (U-937)
Homodimer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1, PER2, CRY1, CRY2, and TIMELESS; interaction with CRY1 and CRY2 is weak and not rhythmic. Interacts with FBXW11 and BTRC.
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For Research Use Only. Not For Clinical Use.