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PHC1

This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein.
Protein class

Disease related genes, Human disease related genes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Astrocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Group enriched (BEWO, NTERA-2, SuSa)

Interaction

Homodimer. Component of a PRC1-like complex (PubMed:12167701, PubMed:19636380, PubMed:21282530). Interacts with RNF2 and CBX7 (By similarity). Interacts with PHC2, PHC2 and BMI1 (By similarity).

Molecular function

Developmental protein, DNA-binding

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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