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PI4KA
Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Excitatory neurons, Inhibitory neurons)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (K-562)
Interaction
Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and FAM126 (FAM126A or FAM126B) (PubMed:23229899, PubMed:24417819, PubMed:26571211). Interacts with TMEM150A; regulating recruitment to the plasma membrane (PubMed:25608530). (Microbial infection) Interacts with CHKA/Choline Kinase-alpha; CHKA bridges PI4KA and hepatitis C virus (HCV) non-structural protein 5A (NS5A) and potentiates NS5A-stimulated PI4KA activity, which then facilitates the targeting of the ternary complex to the ER for viral replication.
Molecular function
Kinase, Transferase
More Types Infomation
- Recombinant Anti-Human PI4KA Antibody (MOB-2823z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, IF, FuncS
- Recombinant Anti-Human PI4KA Antibody scFv Fragment (MOB-2823z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: IP, IF, Biosensors, FuncS
- Recombinant Anti-Human PI4KA Antibody Fab Fragment (MOB-2823z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB, Neut, FuncS
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For Research Use Only. Not For Clinical Use.