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PIM1
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]
Protein class
Cancer-related genes, Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Urothelial cells, Erythroid cells, Suprabasal keratinocytes)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Cell line enhanced (HEL, HMC-1, K-562, U-698)
Interaction
Isoform 1 is isolated as a monomer whereas isoform 2 complexes with other proteins (By similarity). Binds to RP9 (By similarity). Isoform 2, but not isoform 1, binds BMX (PubMed:16186805). Isoform 1 interacts with CDKN1B and FOXO3 (PubMed:18593906). Interacts with BAD (By similarity). Interacts with PPP2CA; this interaction promotes dephosphorylation of PIM1, ubiquitination and proteasomal degradation (PubMed:12473674). Interacts with HSP90AA1, this interaction stabilizes PIM1 protein levels. Interacts (ubiquitinated form) with HSP70 and promotes its proteosomal degradation (PubMed:15798097). Interacts with CDKN1A (PubMed:12431783). Interacts with CDC25C (PubMed:16356754). Interacts (via N-terminal 96 residues) with CDC25A (By similarity). Interacts with MAP3K5 (PubMed:19749799). Interacts with MYC (By similarity). Interacts with CBX3 (PubMed:10664448).
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: ELISA, IHC, WB
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: ICC/IF, IHC-P, WB
-
- Species Reactivity: Human
- Application: IHC-P, WB, sELISA
- Chicken Anti-PIM1 Polyclonal IgY (BRD-0725MZ)
-
- Species Reactivity: Human, Mouse
- Type: Chicken antibody
- Application: WB
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P
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