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PNLIP

PNLIP encodes a member of the lipase family of proteins. The encoded enzyme is secreted by the pancreas and hydrolyzes triglycerides in the small intestine, and is essential for the efficient digestion of dietary fats. Inhibition of the encoded enzyme may prevent high-fat diet-induced obesity in mice and result in weight loss in human patients with obesity. Mutations in this gene cause congenital pancreatic lipase deficiency, a rare disorder characterized by steatorrhea.
Protein class

Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins

Predicted location

Secreted

Single cell type specificity

Cell type enriched (Exocrine glandular cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (U-2 OS)

Interaction

Forms a 1:1 stoichiometric complex with (pro)colipase/CLPS.

Molecular function

Hydrolase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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