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PRKAA2

AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, regulatory beta and gamma subunits. The alpha subunit has two distinct genes, alpha1 and alpha2. AMPK alpha 2 is the serine/threonine kinase catalytic subunit of AMPK. AMPK is responsible for regulating the synthesis of fatty acids and cholesterol.
Protein class

Enzymes, FDA approved drug targets, Metabolic proteins, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Cardiomyocytes, Inhibitory neurons, Rod photoreceptor cells, Excitatory neurons, Oligodendrocyte precursor cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (RPTEC TERT1)

Interaction

AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3) (PubMed:21543851). Interacts with FNIP1 and FNIP2. Associates with internalized insulin receptor/INSR complexes on Golgi/endosomal membranes; PRKAA2/AMPK2 together with ATIC and HACD3/PTPLAD1 is proposed to be part of a signaling network regulating INSR autophosphorylation and endocytosis (PubMed:25687571).

Molecular function

Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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