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PSMD6

This gene encodes a member of the protease subunit S10 family. The encoded protein is a subunit of the 26S proteasome which colocalizes with DNA damage foci and is involved in the ATP-dependent degradation of ubiquinated proteins. Alternative splicing results in multiple transcript variants
Protein class

Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Late spermatids, Early spermatids, Spermatocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enriched (MCF7)

Interaction

Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD6, a base containing 6 ATPases and few additional components.

More Types Infomation

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