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PTBP2
The protein encoded by this gene binds to intronic polypyrimidine clusters in pre-mRNA molecules and is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein (PTB) but most of its isoforms are expressed primarily in the brain. Alternative splicing results in multiple transcript variants.
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Excitatory neurons, Inhibitory neurons)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (RH-30)
Interaction
Monomer. Interacts with NOVA1; the interaction is direct. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Part of a ternary complex containing KHSRP and HNRPH1 (PubMed:11003644, 19029303). Interacts with NOVA2; the interaction is direct (By similarity).
Molecular function
RNA-binding
More Types Infomation
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- Species Reactivity: Human
- Application: WB
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, IHC-P, ICC/IF
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For Research Use Only. Not For Clinical Use.