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PTPN1

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity.
Protein class

Enzymes, Metabolic proteins

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Alveolar cells type 1, monocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Interacts with EPHA3 (phosphorylated); dephosphorylates EPHA3 and may regulate its trafficking and function. Interacts with MET.

Molecular function

Hydrolase, Protein phosphatase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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