Renin

Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.

The research proves that renin angiotensin domain (angiotesin domain, Ang domain) pathways can cause vasoconstriction, fibrosis and vascular smooth muscle cells (vascularsmooth musclecell, VSMC) proliferation, hypertrophy, and studies have shown that renin through the Ang domain way can promote atherosclerosis hair.