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REPS2
The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells)
Immune cell specificity
Group enriched (neutrophil, basophil, eosinophil)
Cell line specificity
Cell line enhanced (HDLM-2, Karpas-707, RH-30, RPMI-8226)
Interaction
Interacts with EPN1; the interaction is direct (PubMed:10393179, PubMed:10557078). Interacts with EPS15; the interaction is direct (PubMed:10393179). Interacts with EPS15L1 (PubMed:10393179). Interacts with RALBP1; can form a ternary complex with activated Ral (RALA or RALB) (PubMed:9422736). Interacts with ASAP1; the interaction is direct and this complex can bind paxillin (PubMed:12149250). Also forms a ternary complex with RALBP1 and ASAP1 (PubMed:12149250). Interacts with GRB2 (PubMed:9422736).
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP
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For Research Use Only. Not For Clinical Use.