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RET
This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis.
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (Horizontal cells, Ionocytes, Skeletal myocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (MCF7, NB-4, SH-SY5Y, THP-1)
Interaction
Phosphorylated form interacts with the PBT domain of DOK2, DOK4 and DOK5 (By similarity). The phosphorylated form interacts with PLCG1 and GRB7 (By similarity). Interacts (not phosphorylated) with PTK2/FAK1 (via FERM domain) (PubMed:21454698). Extracellular cell-membrane anchored RET cadherin fragments form complex in neurons with reduced trophic status, preferentially at the contact sites between somas (PubMed:21357690). Interacts with AIP in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex (PubMed:19366855). Binds to ARTN (By similarity). Interacts (inactive) with CBLC and CD2AP; dissociates upon activation by GDNF which increases CBLC:CD2AP interaction (PubMed:18753381). Interacts (via the extracellular domain) with GFRAL (via the extracellular domain); the interaction mediates cellular signaling upon interaction of GFRAL with its ligand GDF15 (PubMed:28953886, 28846097, 28846099). Interaction with GFRAL requires previous GDF15-binding to GFRAL (PubMed:28846097, 28846099). Interacts with GFRA1; in the presence of SORL1, the GFRA1/RET complex is targeted to endosomes (PubMed:23333276). Interacts with GDNF (PubMed:21994944).
Molecular function
Kinase, Transferase, Tyrosine-protein kinase
More Types Infomation
Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
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- Species Reactivity: Human
- Application: WB
- Recombinant Human Anti-RET Antibody (MHH-844)
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- Derivation: Human
- Type: IgG
- Application: WB, Neut, FuncS
- Recombinant Anti-RET Antibody scFv Fragment (MOB-844-S(P))
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- Derivation: Mouse
- Type: scFv
- Application: FC, Neut, Funcs
- Recombinant Anti-RET Antibody Fab Fragment (MOB-844-F(E))
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- Derivation: Mouse
- Type: Fab
- Application: RIA, WB, FuncS
- Recombinant Anti-RET Antibody (MOB-844)
-
- Derivation: Mouse
- Type: IgG
- Application: ELISA, IP, FuncS
- Recombinant Human Anti-RET Antibody Fab Fragment (MHH-844-F(E))
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- Derivation: Human
- Type: Fab
- Application: ELISA, WB, FC, FuncS
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP, FC
- Recombinant Human Anti-RET Antibody scFv Fragment (MHH-844-S(P))
-
- Derivation: Human
- Type: scFv
- Application: ELISA, WB, FuncS
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, ICC, IP, FC
- Chicken Anti-Human RET Polyclonal IgY (BRD-1148MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB, ICC
- Anti-Human RET Recombinant Antibody (Y078) (TAB-066MZ)
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- Type: Human antibody
- Application: Cyt, IHC, FC
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
- Anti-Human RET Recombinant Antibody scFv Fragment (Y078) (TAB-066MZ-S(P))
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- Type: Human antibody
- Application: IHC
- Anti-Human RET Recombinant Antibody Fab Fragment (Y078) (TAB-066MZ-F(E))
-
- Type: Human antibody
- Application: IHC
- Mouse Anti-RET Recombinant Antibody (clone 8D10C9) (VS3-XY1369)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
- Mouse Anti-RET Recombinant Antibody (clone 6E4C4) (VS3-XY1368)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
- Rabbit Anti-RET Recombinant Antibody (VS3-CJ479) (VS3-CJ479)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, IP, FC
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, FC
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For Research Use Only. Not For Clinical Use.