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RETN

This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Protein class

Candidate cardiovascular disease genes, Plasma proteins

Predicted location

Secreted

Single cell type specificity

Group enriched (Hofbauer cells, Macrophages, monocytes, Kupffer cells)

Immune cell specificity

Group enriched (classical monocyte, myeloid DC, intermediate monocyte, non-classical monocyte)

Cell line specificity

Group enriched (NB-4, U-937)

Interaction

Homodimer; disulfide-linked (By similarity). Interacts with DEFA1 (PubMed:15064728).

Molecular function

Hormone

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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