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RGMA
The RGMA binding proteins, particularly monoclonal antibodies have the ability to bind to RGMA, and therefore neutralize the function of RGMA, for use in the treatment of retinal nerve fiber layer (RNFL) degeneration.
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Astrocytes, Leydig cells, Peritubular cells, Skeletal myocytes, Prostatic glandular cells, Squamous epithelial cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AF22, BEWO, MOLT-4, NTERA-2, REH)
Interaction
Interacts with NEO1, BMP2 and BMP4.
More Types Infomation
Related Signaling Pathways
TGF-β Signaling Pathway
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, ICC/IF
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- Derivation: Human
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Application: ELISA, IHC, FC, IP, IF, FuncS
- Human Anti-RGMA Recombinant Antibody; scFv Fragment (HPAB-0638-CN-S(P)) (HPAB-0638-CN-S(P))
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- Derivation: Humanized
- Species Reactivity: Human, Rat
- Type: Humanized scFv
- Application: ELISA, FC, IF
- Anti-Human RGMA Therapeutical Antibody (TAB-748CL)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
- Human Anti-RGMA Recombinant Antibody (HPAB-0638-CN) (HPAB-0638-CN)
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- Derivation: Humanized
- Species Reactivity: Human, Rat
- Type: Humanized IgG
- Application: ELISA, FC, IF
- Human Anti-RGMA Recombinant Antibody; Fab Fragment (HPAB-0638-CN-F(E)) (HPAB-0638-CN-F(E))
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- Derivation: Humanized
- Species Reactivity: Human, Rat
- Type: Humanized Fab
- Application: ELISA, FC, IF
- Human Anti-RGMA Recombinant Antibody; Fab Fragment (HPAB-0637-CN-F(E)) (HPAB-0637-CN-F(E))
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- Derivation: Chimeric (rat/human)
- Species Reactivity: Human, Rat
- Type: Chimeric (rat/human) Fab
- Application: ELISA, FC, IF
- Rat Anti-RGMA Recombinant Antibody; Fab Fragment (HPAB-0636-CN-F(E)) (HPAB-0636-CN-F(E))
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- Species Reactivity: Human
- Type: Rat Fab
- Application: ELISA
- Rat Anti-RGMA Recombinant Antibody; Fab Fragment (HPAB-0635-CN-F(E)) (HPAB-0635-CN-F(E))
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- Species Reactivity: Human, Rat
- Type: Rat Fab
- Application: ELISA, FC, IF
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- Species Reactivity: Human
- Type: Human IgG
- Application: FC, ELISA
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- Species Reactivity: Human
- Type: Human IgG
- Application: FC, ELISA
-
- Species Reactivity: Human, Rat
- Type: Human IgG
- Application: ELISA
-
- Species Reactivity: Human, Rat
- Type: Human IgG
- Application: ELISA
-
- Species Reactivity: Human, Rat
- Type: Human IgG
- Application: ELISA, Neut, FuncS
- Mouse Anti-RGMA Recombinant Antibody; scFv Fragment (HPAB-0637-CN-S(P)) (HPAB-0637-CN-S(P))
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- Species Reactivity: Human, Rat
- Type: Mouse scFv
- Application: ELISA, FC, IF
- Rat Anti-RGMA Recombinant Antibody; scFv Fragment (HPAB-0636-CN-S(P)) (HPAB-0636-CN-S(P))
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- Species Reactivity: Human
- Type: Rat scFv
- Application: ELISA
- Rat Anti-RGMA Recombinant Antibody; scFv Fragment (HPAB-0635-CN-S(P)) (HPAB-0635-CN-S(P))
-
- Species Reactivity: Human, Rat
- Type: Rat scFv
- Application: ELISA, FC, IF
- Human Anti-RGMA Recombinant Antibody; Fab Fragment (HPAB-0617YY-F(E)) (HPAB-0617YY-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FuncS
- Human Anti-RGMA Recombinant Antibody (HPAB-0637-CN) (HPAB-0637-CN)
-
- Derivation: Chimeric (rat/human)
- Species Reactivity: Human, Rat
- Type: Chimeric (rat/human) IgG1
- Application: ELISA, FC, IF
- Rat Anti-RGMA Recombinant Antibody (HPAB-0636-CN) (HPAB-0636-CN)
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- Species Reactivity: Human
- Type: Rat IgG
- Application: ELISA
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For Research Use Only. Not For Clinical Use.