RIPK2

RIPK2 gene, also known as RIP2, RICK or CARDAK gene, is mainly distributed in the cytoplasm and is widely expressed in various tissues of human body. Its mRNA is highly expressed in peripheral blood leukocytes, heart, placenta, spleen and testis, which is a signal transduction pathway. A key serine-threonine kinase involved in the induction of innate and acquired immune responses mediated by Toll-like receptors and NOD (nucleotide-binding oligomerization domain)-like receptors. It produces inflammatory cytokines. The RIPK2 protein is a 61 kD kinase with a serine/threonine kinase domain at the N-terminus and a caspase activation and recruitment domain (CARD) at the C-terminus. As a protein kinase, RIPK2 plays an important role in maintaining the homeostasis of the immune system. It interacts with NOD1 and NOD2-dependent signaling pathways, which can affect the secretion of inflammatory factors and the activation and recruitment of macrophages. After the infected site, the spleen inner marrow-like cells and T and B lymphocytes can be systemically activated. In innate immunity, RIPK2 has the effect of scavenging extracellular bacteria and plays an important role in host protection against the intracellular pathogen Legionella pneumophila. At the same time, RIPK2 interacts with a variety of proteins, participates in the signal transduction of multiple receptors, and exerts physiological functions.