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RNASE3

The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria.
Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Early spermatids, Late spermatids, Erythroid cells, Kupffer cells, Rod photoreceptor cells, Macrophages)

Immune cell specificity

Immune cell enriched (eosinophil)

Cell line specificity

Cell line enhanced (HL-60, NB-4, THP-1, U-937)

Interaction

Interacts with bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA). In vitro interacts with and insert into lipid bilayers composed of dioleoyl phosphatidylcholine and dioleoyl phosphatidylglycerol. In vitro, tends to form amyloid-like aggregates at pH 3, but not at pH 5, nor 7.

Molecular function

Antibiotic, Antimicrobial, Endonuclease, Hydrolase, Nuclease

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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