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S100A2

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer.
Protein class

Cancer-related genes

Predicted location

Intracellular

Single cell type specificity

Group enriched (Basal keratinocytes, Basal respiratory cells, Prostatic glandular cells, Squamous epithelial cells, Urothelial cells, Basal prostatic cells, Basal squamous epithelial cells, Suprabasal keratinocytes, Club cells)

Immune cell specificity

Immune cell enhanced (basophil)

Cell line specificity

Group enriched (HBEC3-KT, RT4)

Interaction

Homodimer. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity. Interacts with TPPP; this interaction inhibits TPPP dimerization (PubMed:33831707).

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