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SDC2

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types.
Protein class

CD markers

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Hepatocytes, Fibroblasts, Smooth muscle cells)

Immune cell specificity

Immune cell enriched (neutrophil)

Cell line specificity

Cell line enhanced (AF22, EFO-21, fHDF/TERT166, RPTEC TERT1, U-138 MG)

Interaction

Interacts (via cytoplasmic domain) with SARM1 (By similarity). Forms a complex with SDCBP and PDCD6IP (PubMed:22660413).

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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